I think that reduced libido might push you deeper into a depression, I would stop taking it if that were the case, would lookout for an alternative that's easier on the sex drive...
I think the 10 Year old is good motivation to get fit for the 2k run! I would take the challenge and try to pull it off. Arthritis can literally be a pain when running, especially in the cervical...
What I do to deal with jetlag is try to accommodate to the new local time wherever I am as fast as possible, even if it means keeping me awake longer...
I have some experience with Remeron improving sleep, (wasn't taking it for depression though). I think that exercise helps. If this happens every year to you, be glad that it gets better, I would...